Research Study That Points to New Biological Mechanisms in Chronic Kidney Disease, the Subject of Announcement by Ethical Alternative Products.

Wyckoff NJ (PRWEB) March 27, 2014

A study* performed by Ilse Daehn et al. at the Charles Bronfman Institute for Personalized Medicine, Mount Sinai School of Medicine and other prestigious institutions, demonstrated that endothelial mitochondrial oxidative stress (damage to the blood vessel lining that affects the energy-producing part of the cell) regulates the passage of protein from blood to urine and filtration of waste products in the kidney. “Specifically, the researchers found albuminuria (protein in the urine) and depletion of the cells that form the kidney’s glomerular filtration barrier”, stated Erwin Bottinger MD, the study’s senior author.

Chronic kidney disease (CKD) affects more than 10% of the US population, and may lead to end-stage renal disease, and is a major risk factor for cardiovascular disease and mortality. Prevention and reversal of CKD is an urgent public health need. The disease is debilitating and deadly, and existing drugs, at best, offer only mild delay in progression to end-stage kidney failure**.

In preclinical studies, the investigators showed that key cells of the glomerular filtration barrier, also called podocytes, cause alterations in endothelin-1 that triggered disturbances manifested as mitochondrial oxidative stress. The research team was able to confirm that this worked the same way in humans, using kidney biopsies.

Antioxidants that target the mitochondria and endothelin antagonists should alter the paradigm for preventing cell depletion and scarring of the filtration part of the kidney. “There is a pressing unmet need to prevent or reverse chronic kidney disease”, Dr. Bottinger stressed**.

A related study that was recently published in the International J Clin Exp Med, authored by L. Wang et al.*** describes the protective effect of alpha lipoic acid on mitochondria in the kidneys of diabetic rats. The underlying mechanism by which the protective effect against the development of diabetic nephropathy occurred was unknown, but was thought to involve the suppression of the generation of oxidants.

“Oxidative stress has been implicated in a great many chronic diseases, and has now been shown to mediate the progression of the glomerulosclerosis found in most chronic kidney disease” stated Gerald Bruno, Ph.D., CEO of Ethical Alternative Products. “Alpha lipoic acid is recognized as one of the best antioxidants for treatment of oxidative stress and the above animal study demonstrates its effectiveness in protecting against oxidative stress induced glomerular damage. The ThioGel brand of alpha lipoic acid manufactured by Ethical Alternative Products is solubilized for enhanced absorption and bioavailability and is packaged in easy to swallow softgel capsules. Highest quality raw material alpha lipoic acid that is sourced from Europe is used to make the ThioGel product”, stated Bruno.

About Ethical Alternative Products

Ethical Alternative Products is a dietary supplement supplier that is focused on the formulation of scientifically sound natural products that can make a meaningful difference in achieving and maintaining overall well-being, especially with aging. The mission of our senior scientific management is to develop and produce high-value supplements, employing innovative formulations and highest quality raw materials. Products produced by Ethical Alternative Products include ThioGel liquid gel alpha lipoic acid, ThioGel-L triple antioxidant liver formulation, OmniFlex multi-nutrient joint health product and Tendonex topical pain reliever.

*Daehn, I. et al., Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis. J. Clin Invest. 2014 Mar 3

**Study points to new biological mechanisms, treatment paradigm for kidney disease

MedicalXPress Mar 3, 2014.

*** Wang, L. et al The protective effect of α-Lipoic acid on mitochondria in the kidney of diabetic rats.

Int J Clin Exp Med. 2013;6(2):90-7

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